Statins (HMG-CoA Reductase Inhibitors) Decrease Postoperative Adhesions by Increasing Peritoneal Fibrinolytic Activity

摘要

Adhesion formation occurs commonly after abdominal surgery. This occurs in part due to impaired fibrinolysis within the peritoneum, which is primarily governed by the balance between tPA and its inhibitor, PAI-1. Our rat model of adhesions demonstrates that the intraperitoneal administration of statins reduces adhesion formation by up-regulating a profibrinolytic environment.